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Simparica Trio for Dogs

  • Protection against fleas and ticks, intestinal worms and deadly heartworm disease
  • Tasty liver flavoured chew
  • Can be given from 8 weeks of age
  • Veterinarian recommended

What is Simparica Trio?

Simparica Trio is a potent oral formula offering threefold defense for your canine companion. It safeguards against a range of parasites, including fleas, paralysis ticks, intestinal worms, and the potentially lethal heartworm. This oral treatment combines three key ingredients, with moxidectin as a cornerstone component—also a trusted preventive against heartworm in veterinary practice. Simparica Trio not only eliminates fleas and paralysis ticks but also maintains a barrier against these pests for five weeks. It is effective in reducing the threat of tick-borne diseases by targeting paralysis ticks and brown dog ticks. Additionally, it disrupts the flea lifecycle and helps manage flea allergy dermatitis. The chew, with its liver flavor, is designed to be tasty and its monthly administration ensures ongoing comprehensive protection.

The scope of Simparica Trio has expanded, now encompassing the prevention of flea tapeworm infestations, as well as the treatment and control of generalized demodectic mange due to Demodex spp. It also addresses sarcoptic mange caused by Sarcoptes scabiei, significantly ameliorating associated symptoms, and it effectively treats and controls infestations of ear mites (Otodectes cynotis).

Simparica Trio is suitable for dogs from 8 weeks of age and weighing above 1.25kg.


  • It protects dogs against heartworm disease, ticks and fleas, roundworms and hookworms
  • It is a tasty chewable medicine that can be administered once a month
  • It’s safe for young puppies around eight weeks old

What are the side effects of Simparica Trio?

The side effects of Simparica Trio are rare. However, in some clinical trials, vomiting and diarrhea are some of the most adverse reactions. Other adverse side effects include lethargy, hyperactivity, loss of appetite, and increased urination.

What precautions must be taken?

  • The chewable tablets need to remain in their original packaging until use to prevent children’s access to them
  • Hands should be washed after administration of medicine.
  • In cases of accidental medicine swallowing, consult a doctor immediately.

Additional info

  • Mode of administration - Oral
  • Active Ingredients - Sarolaner, Moxidectin & Pyrantel (as embonate)
  • Manufacturer - Zoetis

APVMA Approval Number

  • Simparica Trio for Puppy 1.25-2.5 kg - 88220/136043
  • Simparica Trio for XSmall Dogs 2.6-5 kg - 88219/136039
  • Simparica Trio for Small Dogs 5.1-10 kg - 88218/136037
  • Simparica Trio for Medium Dogs 10.1-20 kg - 88217/136029
  • Simparica Trio for Large Dogs 20.1-40 kg - 88216/136013
  • Simparica Trio for XLarge Dogs 40.1-60 kg - 88214/136006

Simparica Trio

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